Recent Publications

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Nov 16, 2021

Nature chemical biology

David Dilworth, Ronan P Hanley, Renato Ferreira de Freitas, Abdellah Allali-Hassani, Mengqi Zhou, Naimee Mehta, Matthew R Marunde, Suzanne Ackloo, Raquel Arminda Carvalho Machado, Aliakbar Khalili Yazdi, Dominic D G Owens, Victoria Vu, David Y Nie, Mona Alqazzaz, Edyta Marcon, Fengling Li, Irene Chau, Albina Bolotokova, Su Qin, Ming Lei, Yanli Liu, Magdalena M Szewczyk, Aiping Dong, Sina Kazemzadeh, Tigran Abramyan, Irina K Popova, Nathan W Hall, Matthew J Meiners, Marcus A Cheek, Elisa Gibson, Dmitri Kireev, Jack F Greenblatt, Michael-C Keogh, Jinrong Min, Peter J Brown, Masoud Vedadi, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Lindsey I James, Matthieu Schapira

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

Nov 13, 2021

Molecular neurodegeneration

Kevin S Chen, Krystal Menezes, Jarlath B Rodgers, Darren M O'Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P Visanji, Connie Marras, Nour K Majbour, Omar M A El-Agnaf, Andres M Lozano, Joseph Culotti, Satoshi Suo, William S Ryu, Suneil K Kalia, Lorraine V Kalia

Identification of five important genes to predict glioblastoma subtypes

Nov 12, 2021

Neuro-oncology advances

Yang Tang, Maleeha A Qazi, Kevin R Brown, Nicholas Mikolajewicz, Jason Moffat, Sheila K Singh, Paul D McNicholas

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

Nov 12, 2021

Nature communications

Ci Fu, Xiang Zhang, Amanda O Veri, Kali R Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J Polvi, Sean D Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R O'Meara, Matthew J O'Meara, Suzanne Noble, Nicole Robbins, Chad L Myers, Leah E Cowen

Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases

Nov 12, 2021

Journal of molecular biology

Jakub Chrustowicz, Dawafuti Sherpa, Joan Teyra, Mun Siong Loke, Grzegorz M Popowicz, Jerome Basquin, Michael Sattler, J Rajan Prabu, Sachdev S Sidhu, Brenda A Schulman