Selected Publications

Cell invasion in digital microfluidic microgel systems Figure 1

Latest feature: Cell invasion in digital microfluidic microgel systems

In this study, researchers used digital microfluidics to develop a novel in vivo-like microgel system for studying cell invasions. This system allows both imaging of extracellular matrix remodeling (an important aspect of metastasis) as well as collection of invading cell subpopulations for RNA-Seq, synthesizing the strengths of the two main existing tools for in vitro studies of cell invasion.

The study was conducted in the lab of Aaron Wheeler, based here at U of T in the Donnelly Centre. To establish the performance of this assay for yielding RNA-Seq data, and to compare expression between invading and noninvading cells, libraries were run on the NextSeq500 at the Donnelly Sequencing Centre.

Please make sure to shoot us an email when your DSC collaboration is published - we'd like to feature it!


Barutcu, A. R., Wu, M., Braunschweig, U., Dyakov, B. J., Luo, Z., Turner, K. M., ... & Blencowe, B. J. (2022). Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns. Molecular Cell82(5), 1035-1052. [Pubmed]

Biancolin, A. D., Jeong, H., Mak, K. W., Yuan, Z., & Brubaker, P. L. (2022). Disrupted and elevated circadian secretion of glucagon-like peptide-1 in a murine model of type 2 diabetesEndocrinology163(9); [Pubmed]

Erwood, S., Bily, T. M., Lequyer, J., Yan, J., Gulati, N., Brewer, R. A., ... & Cohn, R. D. (2022). Saturation variant interpretation using CRISPR prime editingNature Biotechnology, 1-11; [Pubmed]

Han, H., Mikolajewicz, N., Brown, K., & Moffat, J. (2022). Multi-level cellular and functional annotation of single-cell transcriptomes.[Article]

Kim, B., Sasaki, A., Murphy, K., & Matthews, S. G. (2022). DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment. Translational Psychiatry12(1), 1-8.[Pubmed]

Kim, S. H., Steere, L., Zhang, Y. K., McGregor, C., Hahne, C., Zhou, Y., ... & Cowen, L. E. (2022). Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. ACS Chemical Biology, 17(6),1343–1350, [Pubmed]

Li, B. B., Scott, E. Y., Olafsen, N. E., Matthews, J., & Wheeler, A. R. (2022). Analysis of the effects of aryl hydrocarbon receptor expression on cancer cell invasion via three-dimensional microfluidic invasion assays. Lab on a Chip22(2), 313-325. [Pubmed]

Martchenko, A., Biancolin, A. D., Martchenko, S. E., & Brubaker, P. L. (2022). Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretionScientific reports12(1), 1-14.[Pubmed]

Peterson, J., McTiernan, C. D., Thome, C., Khaper, N., Lees, S. J., Boreham, D. R., ... & Tharmalingam, S. (2022). Identification of Radiation-Induced miRNA Biomarkers Using the CGL1 Cell Model SystemBioengineering9(5), 214. [Pubmed]

Singh, S., Chokshi, C., Tieu, D., Brown, K., Venugopal, C., Rossotti, M., ... & Moffat, J. (2022). Functional discovery of targetable dependencies in recurrent glioblastoma.[Preprint]

Song, J., Nabeel-Shah, S., Pu, S., Lee, H., Braunschweig, U., Ni, Z., ... & Greenblatt, J. F. (2022). Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1Molecular Cell82(17), 3135-3150. [Pubmed]

Khobzey, M. (2022). Exploring different approaches for constructing temperature sensitive alleles of yeast essential genes (Doctoral dissertation, University of Toronto (Canada)). [Proquest]

Ng, K. (2022). Mapping of the Novel mRNA Acetylation, ac4C, in the HEK293 Transcriptome (Doctoral dissertation, University of Toronto (Canada)). [Proquest]


Kelil, A., Gallo, E., Banerjee, S., Adams, J. J., & Sidhu, S. S. (2021). CellectSeq: In silico discovery of antibodies targeting integral membrane proteins combining in situ selections and next-generation sequencing. Communications biology4(1), 1-13. [Pubmed]

Ma, Y., Chen, K., Xia, F., Atwal, R., Wang, H., Ahmed, S. U., ... & Kelley, S. O. (2021). Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture. ACS nano15(12), 19202-19210. [Pubmed]

Maino, E., Wojtal, D., Evagelou, S. L., Farheen, A., Wong, T. W., Lindsay, K., ... & Cohn, R. D. (2021). Targeted genome editing in vivo corrects a Dmd duplication restoring wildtype dystrophin expression. EMBO molecular medicine13(5), e13228.[Pubmed]

Nabeel-Shah, S., Lee, H., Ahmed, N., Burke, G., Farhangmehr, S., Ashraf, K., ... & Greenblatt, J. (2021). SARS-CoV-2 nucleocapsid protein attenuates stress granules and interacts with mRNAs to impair host stress response. Iscience, 25(1):103562. [Pubmed]

Pačnik, K., Ogrizović, M., Diepold, M., Eisenberg, T., Žganjar, M., Žun, G., ... & Natter, K. (2021). Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. BMC genomics22(1), 1-15. [Pubmed]

Stokes, K., Nunes, M., Trombley, C., Flôres, D. E., Wu, G., Taleb, Z., ... & Karpowicz, P. (2021). The circadian clock gene, BMAL1, regulates intestinal stem cell signaling and represses tumor initiation. Cellular and molecular gastroenterology and hepatology, 12(5), 1847-1872. [Pubmed]

Subramanian, A., Hall, M., Hou, H., Mufteev, M., Yu, B., Yuki, K. E., ... & Derry, W. B. (2021). Alternative polyadenylation is a determinant of oncogenic Ras function. Science advances7(51), eabh0562.[Pubmed]

Vaughan, C. A., Singh, S., Subler, M. A., Windle, J. J., Inoue, K., Fry, E. A., ... & Deb, S. (2021). The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3Nature  communications12(1), 1-19. [Pubmed]


Alerasool, N., Segal, D., Lee, H., & Taipale, M. (2020). An efficient KRAB domain for CRISPRi applications in human cells. Nature Methods17(11), 1093-1096.[Nature Methods]

Aregger, M., Lawson, K. A., Billmann, M., Costanzo, M., Tong, A. H., Chan, K., ... & Moffat, J. (2020). Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nature metabolism2(6), 499-513.[Nature Metabolism]

Farini, D., Cesari, E., Weatheritt, R. J., La Sala, G., Naro, C., Pagliarini, V., ... & Sette, C. (2020). A dynamic splicing program ensures proper synaptic connections in the developing cerebellumCell Reports31(9), 107703. [Science Direct]

Gonatopoulos-Pournatzis, T., Niibori, R., Salter, E. W., Weatheritt, R. J., Tsang, B., Farhangmehr, S., ... & Blencowe, B. J. (2020). Autism-misregulated eIF4G microexons control synaptic translation and higher order cognitive functions. Molecular Cell77(6), 1176-1192. [Science Direct]

Kelil, A., Gallo, E., Adams, J., Moffat, J., & Sidhu, S. (2020). CellectSeq: In Silico Discovery of Antibodies Targeting Integral Membrane Proteins Combining In Situ Selections of Phage Displayed Synthetic Antibodies and Next-Generation Sequencing.  [Preprint]

Kim, S. H., Liu, C., Zhou, Y., Zhang, Y. K., McGregor, C., Steere, L., ... & Cowen, L. E. (2020). Inhibiting protein prenylation with benzoxaboroles to target fungal plant pathogens. ACS Chemical Biology15(7), 1930-1941. [ACS Publications]

Lamanna, J., Scott, E. Y., Edwards, H. S., Chamberlain, M. D., Dryden, M. D., Peng, J., ... & Wheeler, A. R. (2020). Digital microfluidic isolation of single cells for-Omics. Nature communications11(1), 1-13. [Pubmed]

Lee, E. S., Wolf, E. J., Smith, H. W., Emili, A., & Palazzo, A. F. (2020). TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes. Nucleic acids research48(20), 11645–11663. [Pubmed]

Li, B. B., Scott, E. Y., Chamberlain, M. D., Duong, B. T., Zhang, S., Done, S. J., & Wheeler, A. R. (2020). Cell invasion in digital microfluidic microgel systems. Science advances6(29), eaba9589. [Link]

Martchenko, S. E., Martchenko, A., Cox, B. J., Naismith, K., Waller, A., Gurges, P., ... & Brubaker, P. L. (2020). Circadian GLP-1 secretion in mice is dependent on the intestinal microbiome for maintenance of diurnal metabolic homeostasis. Diabetes69(12), 2589-2602.[Pubmed]

Nabeel-Shah, S., Lee, H., Ahmed, N., Marcon, E., Farhangmehr, S., Pu, S., ... & Greenblatt, J. F. (2020). SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs. BioRxiv. [Science Direct]

Oh, Y., Yang, S., Liu, X., Jana, S., Izaddoustdar, F., Gao, X., ... & Backx, P. H. (2020). Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised MiceFrontiers in physiology11, 605671. [Pubmed]

Rodrigues, D. C., Mufteev, M., Weatheritt, R. J., Djuric, U., Ha, K. C., Ross, P. J., ... & Ellis, J. (2020). Shifts in ribosome engagement impact key gene sets in neurodevelopment and ubiquitination in Rett syndrome. Cell reports30(12), 4179-4196. [Pubmed]

Sasaki, A., Kim, B., Murphy, K. E., & Matthews, S. G. (2020). Impact of ex vivo sample handling on DNA methylation profiles in human cord blood and neonatal dried blood spots. Frontiers in Genetics11, 224. [Pubmed]

Sinha, A., Saleh, A., Endersby, R., Yuan, S. H., Chokshi, C. R., Brown, K. R., ... & Katyal, S. (2020). RAD51-mediated DNA homologous recombination is independent of PTEN mutational status. Cancers12(11), 3178.[Pubmed]

van Leeuwen, J., Pons, C., Tan, G., Wang, J. Z., Hou, J., Weile, J., ... & Boone, C. (2020). Systematic analysis of bypass suppression of essential genes. Molecular systems biology16(9), e9828. [Pubmed]

Wolf, E. J., Miles, A., Lee, E. S., Nabeel-Shah, S., Greenblatt, J. F., Palazzo, A. F., ... & Emili, A. (2020). MKRN2 physically interacts with GLE1 to regulate mRNA export and zebrafish retinal development. Cell Reports31(8), 107693.[Pubmed]

Reid CG. Investigating the molecular basis for cooperative behaviour in a mutualistic plant-ant. Master's Thesis, University of Toronto. 2020; [TSpace]

Zhai AH. Structural and Functional Characterization of the RING-like Protein RTF2. Doctoral Thesis, University of Toronto. 2020; [TSpace]


Garg, J., Saettone, A., Nabeel-Shah, S., Cadorin, M., Ponce, M., Marquez, S., ...& Fillingham J. (2019). The Med31 conserved component of the divergent mediator complex in Tetrahymena thermophila participates in developmental regulation. Current Biology, 29(14), 2371–2379.e6. [Pubmed]

Laverty, K. U., Stout, J. M., Sullivan, M. J., Shah, H., Gill, N., Holbrook, L., ... & van Bakel, H. (2019). A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci. Genome research29(1), 146–156.. [Pubmed]

Magomedova, L., Tiefenbach, J., Zilberman, E., Le Billan, F., Voisin, V., Saikali, M., …& Cummins, C. L. (2019). ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Nucleic acids research47(6), 2856–2870.[Pubmed]

Mair, B., Tomic, J., Masud, S. N., Tonge, P., Weiss, A., Usaj, M., ...& Moffat, J. (2019). Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell reports27(2), 599–615.e12. [Pubmed]

McAuley, S., Huynh, A., Howells, A., Walpole, C., Maxwell, A., & Nodwell, J. R. (2019). Discovery of a novel DNA gyrase-targeting antibiotic through the chemical perturbation of Streptomyces venezuelae sporulation. Cell chemical biology26(9), 1274-1282[Pubmed]

Saettone, A., Ponce, M., Nabeel-Shah, S., Fillingham, J.(2019). RACS: rapid analysis of ChIP-Seq data for contig based genomes. BMC Bioinformatics. 2019; 20(533); [Pubmed]

Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., …& Huang, A. (2019). A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain TumorCancer cell36(1), 51–67.e7 [Pubmed]

Vinals, D. F., Kitov, P. I., Tu, Z., Zou, C., Cairo, C. W., Lin, H. C. H., & Derda, R. (2019). Selection of galectin3 ligands derived from genetically encoded glycopeptide librariesPeptide Science111(1), e24097. [Pubmed]

Xiao, H., Li, C., Al Rwahnih, M., Dolja, V., & Meng, B. (2019). Metagenomic analysis of riesling grapevine reveals a complex virome including two new and divergent variants of grapevine leafroll-associated virus 3Plant disease103(6), 1275-1285. [Pubmed]

Zhao, Y., Rafatian, N., Feric, N. T., Cox, B. J., Aschar-Sobbi, R., Wang, E. Y., ... & Radisic, M. (2019). A platform for generation of chamber-specific cardiac tissues and disease modelingCell176(4), 913-927. [Pubmed]

Ng, M. K. (2019). Characterization of Nucleosomes Containing Specific Forms of the Histone Variant H2A. Z. Doctoral Thesis, York University.[Yorkspace]


Davis GM, Tu S, Anderson JW, Colson RN, Gunzburg MJ, Francisco MA, Ray D, Shrubsole SP, Sobotka JA, Seroussi U, Lao RX, Maity T, Wu MZ, McJunkin K, Morris QD, Hughes TR, Wilce JA, Claycomb J, Weng Z, Boag PR. The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans. e. eLife. 2018; 7:. [Pubmed]

Ma YV, Xu L, Mei X, Middleton K, You L. Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signaling through endothelial cells. Journal of Cellular Biochemistry. 2018; [Pubmed]

Gonatopoulos-Pournatzis T, Wu M, Braunschweig U, Roth J, Han H, Best AJ, Raj B, Aregger M, O'Hanlon D, Ellis JD, Calarco JA, Moffat J, Gingras AC, Blencowe BJ. Genome-wide CRISPR-Cas9 interrogation of splicing networks reveals a mechanism for recognition of autism-misregulated neuronal microexons. Molecular Cell. 2018; 72(3):510-524.e12. [Pubmed]

Ng S, Bennett NJ, Schulze J, Gao N, Rademacher C, Derda R. Genetically-encoded fragment-based discovery of glycopeptide ligands for DC-SIGN. Bioorganic & Medicinal Chemistry. 2018; 26(19):5368-5377. [Pubmed]

Sterne-Weiler T, Weatheritt RJ, Best AJ, Ha KCH, Blencowe BJ. Efficient and accurate quantitative profiling of alternative splicing patterns of any complexity on a laptop. Molecular Cell. 2018; 72(1):187-200.e6. [Pubmed]

Veri AO, Miao Z, Shapiro RS, Tebbji F, O'Meara TR, Kim SH, Colazo J, Tan K, Vyas VK, Whiteway M, Robbins N, Wong KH, Cowen LE. Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space. PLoS genetics. 2018; 14(3):e1007270. [Pubmed]

Midhat U, Ting MKY, Teresinski HJ, Snedden WA. The calmodulin-like protein, CML39, is involved in regulating seed development, germination, and fruit development in Arabidopsis. Plant Molecular Biology. 2018; 96(4-5):375-392. [Pubmed]


Cai Q, Ye X, Chen B, Zhang B. Complete genome sequence of Exiguobacterium sp. strain N4-1P, a psychrophilic bioemulsifier producer isolated from a cold marine environment in North Atlantic Canada. Genome Announcements. 2017; 5(44):. [Pubmed]

Ilves KL, Torti D, López-Fernández H. Exon-based phylogenomics strengthens the phylogeny of Neotropical cichlids and identifies remaining conflicting clades (Cichliformes: Cichlidae: Cichlinae). Molecular Phylogenetics and Evolution. 2018; 118:232-243. [Pubmed]

Moisiadis VG, Constantinof A, Kostaki A, Szyf M, Matthews SG. Prenatal glucocorticoid exposure modifies endocrine function and behaviour for 3 generations following maternal and paternal transmission. Scientific Reports. 2017; 7(1):11814. [Pubmed]

Loll-Krippleber R, Brown GW. P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance. Nature Communications. 2017; 8(1):558. [Pubmed]

Xiong X, Bales ES, Ir D, Robertson CE, McManaman JL, Frank DN, Parkinson J. Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine. Microbiome. 2017; 5(1):117. [Pubmed]

Tapial J, Ha KCH, Sterne-Weiler T, Gohr A, Braunschweig U, Hermoso-Pulido A, Quesnel-Vallières M, Permanyer J, Sodaei R, Marquez Y, Cozzuto L, Wang X, Gómez-Velázquez M, Rayon T, Manzanares M, Ponomarenko J, Blencowe BJ, Irimia M. An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms. Genome Research. 2017; 27(10):1759-1768. [Pubmed]

Gueroussov S, Weatheritt RJ, O'Hanlon D, Lin ZY, Narula A, Gingras AC, Blencowe BJ. Regulatory expansion in mammals of multivalent hnRNP assemblies that globally control alternative splicing. Cell. 2017; 170(2):324-339.e23. [Pubmed]

Loiselle JJ, Roy JG, Sutherland LC. RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5. PLoS One. 2017; 12(6):e0180258. [Pubmed]

Akkouche A, Mugat B, Barckmann B, Varela-Chavez C, Li B, Raffel R, Pélisson A, Chambeyron S. Piwi is required during Drosophila embryogenesis to license dual-strand piRNA clusters for transposon repression in adult ovaries. Molecular Cell. 2017; 66(3):411-419.e4. [Pubmed]

Vaughan CA, Singh S, Grossman SR, Windle B, Deb SP, Deb S. Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells. Molecular Oncology. 2017; 11(6):696-711. [Pubmed]

Singh S, Vaughan CA, Frum RA, Grossman SR, Deb S, Palit Deb S. Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication. The Journal of Clinical Investigation. 2017; 127(5):1839-1855. [Pubmed]

AlZahal O, Li F, Guan LL, Walker ND, McBride BW. Factors influencing ruminal bacterial community diversity and composition and microbial fibrolytic enzyme abundance in lactating dairy cows with a focus on the role of active dry yeast. Journal of Dairy Science. 2017; 100(6):4377-4393. [Pubmed]

Burns AR, Bagg R, Yeo M, Luciani GM, Schertzberg M, Fraser AG, Roy PJ. The novel nematicide wact-86 interacts with aldicarb to kill nematodes. PLoS Neglected Tropical Diseases. 2017; 11(4):e0005502. [Pubmed]

Han H, Braunschweig U, Gonatopoulos-Pournatzis T, Weatheritt RJ, Hirsch CL, Ha KCH, Radovani E, Nabeel-Shah S, Sterne-Weiler T, Wang J, O'Hanlon D, Pan Q, Ray D, Zheng H, Vizeacoumar F, Datti A, Magomedova L, Cummins CL, Hughes TR, Greenblatt JF, Wrana JL, Moffat J, Blencowe BJ. Multilayered control of alternative splicing regulatory networks by transcription factors. Molecular Cell. 2017; 65(3):539-553.e7. [Pubmed]

Mentasti M, Cassier P, David S, Ginevra C, Gomez-Valero L, Underwood A, Afshar B, Etienne J, Parkhill J, Chalker V, Buchrieser C, Harrison TG, Jarraud S; ESCMID Study Group for Legionella Infections (ESGLI). Rapid detection and evolutionary analysis of Legionella pneumophila serogroup 1 sequence type 47. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 2017; 23(4):264.e1-264.e9. [Pubmed]

Leach MD, Kim T, DiGregorio SE, Collins C, Zhang Z, Duennwald ML, Cowen LE. Candida albicans is resistant to polyglutamine aggregation and toxicity. G3 (Bethesda, MD.). 2017; 7(1):95-108. [Pubmed]


Quesnel-Vallières M, Dargaei Z, Irimia M, Gonatopoulos-Pournatzis T, Ip JY, Wu M, Sterne-Weiler T, Nakagawa S, Woodin MA, Blencowe BJ, Cordes SP. Misregulation of an activity-dependent splicing network as a common mechanism underlying autism spectrum disorders. Molecular Cell. 2016; 64(6):1023-1034. [Pubmed]

Soloveychik M, Xu M, Zaslaver O, Lee K, Narula A, Jiang R, Rosebrock AP, Caudy AA, Meneghini MD. Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation. Scientific Reports. 2016; 6:37942. [Pubmed]

Lee JA, Robbins N, Xie JL, Ketela T, Cowen LE. Functional genomic analysis of Candida albicans adherence reveals a key role for the Arp2/3 complex in cell wall remodelling and biofilm formation. Molecular Cell. 2016; 12(11):e1006452. [Pubmed]

Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Research. 2016; 26(12):1742-1752. [Pubmed]

van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M1 VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, Cao J, Cote A, Gebbia M, Horecka G, Horecka I, Kuzmin E, Legro N, Liang W, van Lieshout N, McNee M, San Luis BJ, Shaeri F, Shuteriqi E, Sun S, Yang L, Youn JY, Yuen M, Costanzo M, Gingras AC, Aloy P, Oostenbrink C, Murray A, Graham TR, Myers CL, Andrews BJ, Roth FP, Boone C. Exploring genetic suppression interactions on a global scale. Science (New York, N.Y.). 2016; 354(6312). [Pubmed]

Liang L, Gnaneshan S, Garduño RA, Mallo GV. Genome sequence of Listeria monocytogenes Plasmid pLM-C-273 carrying genes related to stress resistance. Genome Announcements. 2016; 4(5):. [Pubmed]

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. Nature Chemical Biology. 2016; 12(10):867-75. [Pubmed]

Tsalikis J, Pan Q, Tattoli I, Maisonneuve C, Blencowe BJ, Philpott DJ, Girardin SE. The transcriptional and splicing landscape of intestinal organoids undergoing nutrient starvation or endoplasmic reticulum stress. BMC Genomics. 2016; 17:680. [Pubmed]

Teatero S, Lemire P, Dewar K, Wasserscheid J, Calzas C, Mallo GV, Li A, Athey TB, Segura M, Fittipaldi N. Genomic recombination leading to decreased virulence of group B Streptococcus in a mouse model of adult invasive disease. Pathogens (Basel, Switzerland). 2016; 5(3):. [Pubmed]

Wang Y, White MM, Moncalvo JM. Draft genome sequence of Capniomyces stellatus, the obligate gut fungal symbiont of stonefly. Genome Announcements. 2016; 4(4):. [Pubmed]

Rodor J, Pan Q, Blencowe BJ, Eyras E, Cáceres JF. The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation. RNA (New York, N.Y.). 2016; 22(9):1411-26. [Pubmed]

Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Scientific Reports. 2016; 6:27204. [Pubmed]

Stubenhaus BM, Dustin JP, Neverett ER, Beaudry MS, Nadeau LE, Burk-McCoy E, He X, Pearson BJ, Pellettieri J. Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias. eLife. 2016; 5:. [Pubmed]

Wisnovsky S, Jean SR, Kelley SO. Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes. Nature Chemical Biology. 2016; 12(7):567-73. [Pubmed]

Sharma E, Sterne-Weiler T, O'Hanlon D, Blencowe BJ. Global mapping of human RNA-RNA interactions. Molecular Cell. 2016; 62(4):618-26. [Pubmed]

Labrie V, Buske OJ, Oh E, Jeremian R, Ptak C, Gasiūnas G, Maleckas A, Petereit R, Žvirbliene A, Adamonis K, Kriukienė E, Koncevičius K, Gordevičius J, Nair A, Zhang A, Ebrahimi S, Oh G, Šikšnys V, Kupčinskas L, Brudno M, Petronis A. Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging. Nature Structural & Molecular Biology. 2016; 23(6):566-73. [Pubmed]

Herman AC, Schoen DJ. Recent selection for self-compatibility in a population of Leavenworthia alabamica. Evolution; International Journal of Organic Evolution. 2016; 70(6):1212-24. [Pubmed]

D'Souza SA, Rajendran L, Bagg R, Barbier L, van Pel DM, Moshiri H, Roy PJ. The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans. Molecular Cell. 2016; 12(4):e1006010. [Pubmed]

Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Molecular Systems Biology. 2016; 12(4):863. [Pubmed]

Winick-Ng W, Caetano FA, Winick-Ng J, Morey TM, Heit B, Rylett RJ. 82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions. Scientific Reports. 2016; 6:23914. [Pubmed]

Currie KW, Brown DD, Zhu S, Xu C, Voisin V, Bader GD, Pearson BJ. HOX gene complement and expression in the planarian Schmidtea mediterranea. EvoDevo. 2016; 7:7. [Pubmed]

Rao C, Guyard C, Pelaz C, Wasserscheid J, Bondy-Denomy J1 Dewar K, Ensminger AW. Active and adaptive Legionella CRISPR-Cas reveals a recurrent challenge to the pathogen. Cellular Microbiology. 2016; 18(10):1319-38. [Pubmed]

Gnaneshan S, Hsueh YC, Liang L, Teatero S, Fittipaldi N, Mallo GV. Genome sequence of Listeria monocytogenes strain F6540 (sequence type 360) collected from food samples in Ontario, Canada. Genome Announcements. 2016; 4(1). [Pubmed]

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