Jun 3, 2021

Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches

Punit Saraon, Shivanthy Pathmanathan, Jamie Snider, Anna Lyakisheva, Victoria Wong, Igor Stagljar
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK dysregulation have been identified, resulting in multiple cancer types displaying 'oncogenic addiction' to RTKs. As a result, RTKs have represented a major class for targeted therapeutics over the past two decades, with numerous small molecule-based tyrosine kinase inhibitor (TKI) therapeutics having been developed...