Feb 13, 2024
Engineering Biomaterials to Model Immune-Tumour Interactions In Vitro
Advanced materials (Deerfield Beach, Fla.)
Engineered biomaterial scaffolds are becoming more prominent in research laboratories to study drug efficacy for oncological applications in vitro, but do they have a place in pharmaceutical drug screening pipelines? The low efficacy of cancer drugs in phase II/III clinical trials suggests that there are critical mechanisms not properly accounted for in the pre-clinical evaluation of drug candidates. Immune cells associated with the tumour may account for some of these failures given recent...