Ashley Libby

During embryonic development, stem cells must interpret signals, adopt specific identities, and move into position as tissues form. Physical tissue shaping (morphogenesis) occurs alongside gene expression changes that determine cell fate, raising the question of how these processes are coordinated. The Libby Lab studies how epigenetic state informs gene expression amid changing signals and tissue shapes, generating feedback loops that further drive morphogenesis. Using the developing neural tube as a model, we examine the complex process of spine formation. This work reveals general principles of organ development and helps identify where these processes fail in disorders such as spina bifida.

More specific research interests concern:

- Secondary neurulation gene regulation

- Epigenetic-signaling receptor interactions

- Tissue architecture control over signal reception