Discovery Genomics
Donnelly Centre Research Themes
Our faculty have made significant breakthroughs in functional genomics, proteomics and metabolomics, forming a strong foundation for biomedical research. We are pioneers in high-throughput methods that advance our understanding of gene function. Our ongoing work aims to make the human genome more accessible and easier to interpret, helping to reveal how cells and tissues function and guiding drug discovery.
Discovery Genomics News
Jun 2, 2026
When considering regions of genomes that encode proteins, human DNA is approximately 99% identical to that of chimpanzees. But genetic code similarity does not tell the full evolutionary story. A new study by Blencowe Lab researchers has illuminated a potentially frequent mechanism that generates evolutionary divergence between primate species.
May 25, 2026
The study used the Stagljar Lab-designed Mammalian Membrane Two-Hybrid technology to reveal how two major drivers in glioblastoma "talk" to each other to promote tumour growth. They also discovered how to disrupt that communication.
Apr 8, 2026
The Krause Lab has discovered a new potential treatment avenue for debilitating conditions like Inflammatory Bowel Disease. By investigating one of the main controllers of lipid storage in the human body, the researchers identified a small molecule produced by gut microbes that protects against colon inflammation.
Oct 7, 2025
Dr. Khalid Al-Zahrani’s new lab at the University of Toronto will use novel CRISPR applications and functional genomics to identify the genes that drive cancer growth, and develop targeted therapies. His research lab, situated on the third floor of the Donnelly Centre, is empty: the shelves, desks, and benches wait to be occupied. He has plans for every space.