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Jack Greenblatt retires from teaching after 49 years of professorship
As Jack Greenblatt gives a speech at his retirement party, he reminds the crowd, again, that he is not actually retiring. No one who knows Jack personally is surprised; even at 80 years old, the trailblazer still has five years of grants left and concrete plans to carry out the research paths he’s been following for nearly five decades.
“Amazingly, half a century after I began studying transcriptional anti-termination in E. coli at the University of Toronto, we are still studying transcription termination and anti-termination,” says Greenblatt. “Only now our focus is on cleavage and polyadenylation, which regulate transcription termination in human and other eukaryotic cells.”
“A peculiarity in Jack's career is that he really ended up doing a lot with termination,” jokes long-time colleague Tim Hughes, Donnelly PI and Chair of Molecular Genetics. “This introduces a kind of paradox, because termination is one of the things preventing Jack himself from stopping.”
After coming to U of T in 1977, Greenblatt made his academic home in the old Banting and Best Department of Medical Research (BBDMR). Because the containment lab needed to do his research hadn’t been built yet, Greenblatt spent his first few months working on a temporary bench in one of the building hallways.
“I remained in that small brick building at College and University for 29 years, until the Donnelly Centre was built,” Greenblatt recalls. “When I arrived in Toronto in 1977, there was very little that could be considered molecular biology. Now, the Molecular Genetics department alone has about 110 faculty, and there are hundreds of other faculty in other departments who are using the methods of molecular biology. It's an entirely different university from the one that I arrived at.”
“Jack may be the one continuous and recognizable feature that links all variations of the Department of Molecular Genetics together, and thus, could be considered a defining feature of our department,” says Hughes. “Like another archetype, the coelacanth, Jack himself is virtually unchanged from the time I got here in 2001. At the time, he was already well known for his hands-off supervisory style—which produces a great deal of anxiety in the graduate office... while also regularly producing strong and independent minds.”
Colleagues, family, and past and present students gathered at the Faculty Club to celebrate this milestone in Greenblatt’s life, and a half-century of trailblazing research.
“There's a famous hockey player that said you need to skate where the puck goes, not where it is,” says Stephane Angers, PI, professor, and director of the Donnelly Centre. “Jack has anticipated where biology was going his whole career.”
In his speech, Greenblatt outlines his career concisely: from attempting to understand transcriptional termination and anti-termination, to using protein affinity chromatography to identify protein-protein interactions, to his group’s effort in the 2000s to identify protein-protein interactions on a genome-wide scale.
“More than ever, I still want to continue participating in research,” Greenblatt says. “When I began my career nearly 60 years ago, I strongly believed in the value of research to society. That hasn't changed.”
As retired faculty, Greenblatt will still be involved in research, but will no longer be running Regulation of Gene Expression, a course he’s been teaching for over forty years.
"Amazingly, the content is as relevant now to biomedical science as it was when I started teaching it,” says Greenblatt. “The actual topics in the course have changed drastically over the years, but the importance of the course hasn’t changed.”
As the crowd raises a glass to Greenblatt, it’s not a toast to his retirement, but a celebration of ongoing and thriving research.
“On behalf of everybody at Donnelly, I would like to congratulate you and say thank you for this amazing career,” says Angers, laughing. “I’d like to say it, but it's not over yet. So, congratulations Jack, on retiring from 20% of your job.”
About the Donnelly Centre
The Donnelly Centre for Cellular and Biomolecular Research is a research hub at the University of Toronto’s Temerty Faculty of Medicine, where scientists from diverse fields work together to advance medicine and health. Founded in 2005, the Donnelly Centre is a global leader in research on systems biology, regenerative medicine and disease modelling.
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